New team member

New postdoc in the ANGIOGENESIS & METABOLISM LABORATORY

On January 1, Dr. Anuradha Doddaballapur joined the ANGIOGENESIS & METABOLISM LABORATORY as a new postdoctoral scientist. Anuradha did her Ph.D. at the Institute of Cardiovascular Regeneration in Frankfurt, where she worked under the mentorship of Dr. Reinier Boon and Prof. Dr. Stefanie Dimmeler. During her Ph.D., she studied the regulation of endothelial metabolism by shear stress and the transcription factor KLF2 (see references below). She will now focus on the regulation of ubiquitin signaling in the endothelium as well as its relevance to angiogenic blood vessel growth.

Bibliography

Fontijn RD, Volger OL, van der Pouw-Kraan TC, Doddaballapur A, Leyen T, Baggen JM, Boon RA, Horrevoets AJ. Expression of Nitric Oxide-Transporting Aquaporin-1 Is Controlled by KLF2 and Marks Non-Activated Endothelium In Vivo. PLoS One. 2015 Dec 30;10(12):e0145777.

Demolli S, Doebele C, Doddaballapur A, Lang V, Fisslthaler B, Chavakis E, Vinciguerra M, Sciacca S, Henschler R, Hecker M, Savant S, Augustin HG, Kaluza D, Dimmeler S, Boon RA. MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2. J Mol Cell Cardiol. 2015 Nov;88:111-9.

Doddaballapur A, Michalik KM, Manavski Y, Lucas T, Houtkooper RH, You X, Chen W, Zeiher AM, Potente M, Dimmeler S, Boon RA. Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3. Arterioscler Thromb Vasc Biol. 2015
Jan;35(1):137-45.

Michalik KM, You X, Manavski Y, Doddaballapur A, Zörnig M, Braun T, John D, Ponomareva Y, Chen W, Uchida S, Boon RA, Dimmeler S. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res. 2014 Apr 25;114(9):1389-97